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Salvia Versus DMT – Two Different Trips

Salvia Versus DMT – Two Different Trips

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August 3, 2014 By John Reed Leave a Comment

Salvia Versus DMT – Two Different Trips

salvia                                                 dmt crystals

Intro

There are countless ways to experience psychedelic hallucinations in the modern world thanks to Salvia and DMT. The ancient world continues to provide plants and active ingredients to take the human mind away from reality for awhile. Common, naturally derived substances like Salvia and DMT provide a non-synthetic window into a different world of experiences. People have been using both of these substances for centuries. The effects are not necessarily consistent or controllable but Salvia and DMT are drugs which are known for producing visual hallucinations. These substances have different laws and legal status in place in the US and around the world to restrict their use. Regardless of legal status, Salvia and DMT are available in different forms world wide.

Salvia

Salvia can be grown inside or outdoors by anyone and you can easily buy Salvia online. Salvia plant material can be reduced to a tincture or extract to intensify the hallucination experience. DMT is not as easy to make or find compared to Salvia. Both Salvia and DMT are most commonly smoked, and are considered by many veterans of the experiences to have similar effects. Looking at the active ingredients and chemical make up of these substances can help explain their effects.

For many years, Salvia divinorum was taken orally (and sometimes smoked) by the native people of Oaxaca Mexico. In the Sierra Mazateca Mountains, this perennial herb naturally grows and is cultivated by clippings in other places. The active ingredient of this plant is known as Salvinorin A. This ingredient “Salvinorin A”, when smoked from the plant, interacts with the brain through neurotransmitters. The physiological effects are very unique to the Salvinorin A compound and cannot be found elsewhere, not even in other Salvia plants.

Smoking a standard leaf of the Salvia divinorum plant is the most simple and low dose way a person to experience effects. The immediate acute effects which include visual hallucinations and feelings of floating are known for lasting around 10 minutes. Many people describe their personal experiences as visually pleasant and also as very introspective. The world will be experienced differently under the hallucination effects, but a whole new world is not totally created for most people. The after effects vary from person to person but most commonly include improved mood and feelings of connection to the universe and nature. Youtube has archives of Salvia trips that some medical professionals are now using to study Salvia to get a better understanding of the substance.

DMT ( Dimethyltryptamine ) 

DMT, formally known as NN-Dimethyltryptamine is a psychedelic compound that can be taken in several different ways. The modern and most commonly used form of DMT is smokable and vaporizable. DMT is commonly found combined with an MAOI (monoamine oxisade inhibitor) rich plant known as “changa”. Changa is enhanced with DMT to create a modernized version of Ayahuasca – a psychedelic brew from the amazon, and surround Central American and South American regions. The combination of DMT with an MAOI is done to activate the compound and allows for psychedelic effects to be experienced.

The short-acting effects of DMT are described as very intense, and many people experience full immersion into a different world or reality. The blood brain barrier is breached with DMT allowing for intense mental effects. Perspective shifts and changes are nearly inevitable. Insight revelations are also typical during a DMT trip. It is common for a person to feel deep spiritual awakenings or rebirth. The visual open eye hallucinations are often hard to describe after the trip, it can be so new and perfectly abstract that there are not words to describe what a person see’s. The DMT dose, form of ingestion, and mood/environmental factors can dictate how intense a DMT trip will be. Typical trip lengths last between 6-20 minutes according to Erowid reports. There are no common reported hangover feelings or after effects which linger longer than an hour.

Similarities and Differences

DMT is considered a far more powerful psychedelic than Salvia. There are some Salvia extracts of 60x strength or more which are concentrated to produce much more intense and DMT like effects. The two substances both provide hallucinations but different depths and types of hallucinations are experienced. The experiences cannot be the same because the active ingredients are different.

The two different trips from these substances are both short, and share a range of insightful effects. Smoking can be hard on the lungs for some people and vaporization or other forms may be less physically harsh. A safe and pleasant location is best for any trips that can feature visuals and quick acting effects. Some may find the effects to be trance like for both Salvia and DMT. It may be hard for any person to describe their experience after a trip, the effects are deeply personal and divine in nature.

Reference for DMT: https://www.erowid.org/chemicals/dmt/dmt_effects.shtml

Filed Under: Salvia Divinorum (Ska Pastora) Tagged With: buy salvia, Dimethyltryptamine, DMT, salvia divinorum, salvia versus DMT

Top 10 Psychedelic Youtube Compilation – Salvia Music

Top 10 Psychedelic Youtube Compilation – Salvia Music

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July 24, 2014 By John Reed Leave a Comment

Top 10 Psychedelic Youtube Compilation – Salvia Music

We are featuring our top 10 picks of our favourite Youtube music videos. These Salvia Music videos fit with the genre of Psychedelic music.

Our Top 10 Salvia Music list is meant as an auditory guide. You can watch these Salvia Music videos for the visuals, although it will not necessarily enhance your Salvia experience. We believe that Salvia in itself provides the necessary juice required to create its own interesting visual stimuli. Check out a few of the reported Salvia Effects that you can expect to experience.

When doing Salvia we recommend you take the time to detach yourself from your computer. Close your eyes let the music guide you and let your subconscious be the instrument of the required visual stimuli.  Prior to commencing a Salvia trip check our Smoking Salvia Guide. You may also want to read up on a few of Salvia Trip reports prior to commencing.  Once you are ready to buy Salvia, let this guide be an inspiration to your Salvia Trip.

How We Picked Out Our List

Our rankings for our top 10 list of Salvia music videos are based the following factor:

  • Music tempo – We ranked videos based on the subtly of the music. How soft and soothing the music was.
  • Lyrics – How appropriate lyrics were to a proper Psychedelic Salvia experience

We associated a ranking that was based on the above mentioned categories with a ranking that ranges on a scale of 1 to 5. A Salvia experience is nothing like your average psychedelic experience negative or the wrong kind of words will just tend to freak you out.

1. The Beatles – Tomorrow Never Knows (Mono)

Music Tempo – 4/5
Lyrics – 4.8/5

2. The American Metaphysical Circus – The United States of America

Music Tempo – 3.8/5
Lyrics – 4.5/5

3. Grace – Country Joe & The Fish

Music Tempo – 3.0/5
Lyrics – 5/5

4. Interstellar Overdrive – Pink Floyd

Music Tempo – 3.2/5
Lyrics – 5/5

5. Are You Experienced – Jimi Hendrix Experience

Music Tempo – 3.3/5
Lyrics – 4.1/5

6. At The Mountains of Madness – H.P. Lovecraft

Music Tempo – 3.3/5
Lyrics – 4/5

7. Strawberry Fields Forever – The Beatles

Music Tempo – 3/5
Lyrics – 4.2/5

8. Dark Star – Grateful Dead

Music Tempo – 4/5
Lyrics – 2/5

9. Bass Strings – Country Joe & The Fish

Music Tempo – 3/5
Lyrics – 3/5

10. Spare Chaynge – Jefferson Airplane

Music Tempo – 4/5
Lyrics – 2.9/5

 

Disclaimer 1: Don’t forget to skip the commercials before using it to help your experience. Remember Salvia lasts for a maximum of maybe 10 minutes.

Disclaimer: None of our staff tried to watch these Salvia Music videos while on Salvia. Therefore we expect the user experience to vary.  A few factors you should keep in mind prior to attempting Salvia:

  • Avoid Salvia if you are feeling depressed
  • Avoid Salvia if you are on medication
  • Do not consume legal or illegal substances while trying Salvia
  • Do not consume Salvia in a Party setting

 

 

Filed Under: Salvia Divinorum (Ska Pastora) Tagged With: buy salvia, music and salvia, salvia, Salvia Effects, Salvia Music, Top 10 Psychedelic Music

Philosophy vs Party – Salvia fights modern day use

Philosophy vs Party – Salvia fights modern day use

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July 9, 2014 By John Reed 1 Comment

Philosophy vs Party – Salvia fights modern day use

Originally the plant Salvia divinorum was cultivated by mountain people of the Mazatec region. It was used through the past in different ways but often for the same reason. Most often, it was consumed orally, with some evidence showing history of smoking as well. For the effects it was used, a sacred ritual of introspection that these mountain people valued and had pride in. When salvia is taken orally, the effects are different than modern day methods of smoking.

Salvia

The cultural Mazatec use of salvia was spiritual in nature. The partying of modern times is for escape most often, not to look into one’s soul or peer into the nature of the universe. Salvia was for a long time, used as a means of deepening a persons relationship with themselves and their spirit. Daniel Siebert is quoted as saying people often have “profound insights during salvia experiences”. Salvia is said to induce some vision interference and cause a dream like feeling for the person tripping. After effects can vary just as much as individual trip experiences.

Salvia liquid tinctureQuality of experience can vary based on method of salvia use. Tinctures, extracts, oral consumption, smoking, the list of ways to consume salvia goes on. Most salvia that is grown in the world today is genetically identical thanks to clipping propagation. The plant is typically grown and exported from Mexico. Trip effects are going to depend on the strength and quality and individual persons mental status. Salvia extracts and tinctures can be made at different strengths at home from dried salvia leaves or bought online.

Thanks to the internet and social media, it is easy enough to find ways and means to remove yourself from reality. For those who may be inexperienced, youtube offers some instructional videos for countless things. There are many herbal supplements used to escape reality, but a quote from the 2009 joergo.de interview with Daniel Siebert in reference to Salvia says, “Salvia is not an escapist drug. Quite the contrary it is a philosopher’s tool”.

Often a person will try tripping on Salvia around other people. There are countless videos (again) of this online for the curious mind to pour over or have a laugh. Rarely is it discussed or filmed that Salvia is best used alone. This is the easiest way to unlock the introspective part of the plant. Daniel Seibert is again quoted on this topic “Salvia provides access to parts of the psyche that are normally out of reach. For this reason, people often learn a lot about themselves during salvia trips.” There is no right or wrong way to use it of course. A person just may benefit in different ways based on their use and environment.

In black and white, many herbs and supplements are abused with high doses and a brutish mental attitude. Salvia is no exception to the social norm of tripping around other people. The issue lies with instructional videos and guides conveying an inappropriate purpose behind the use of the drugs. A lack of facts can cause a person to use something like Salvia for the wrong reasons it was once grown for.

This philosopher’s drug cannot exist in nature on it’s own. The Salvia divinorum plant most almost always grow from the help of humans. It must be clipped and replanted carefully to grow again. This shows commitment of a serious nature. The same attitude should be carried over into the use of salvia, as a philosopher’s tool not a party source. If a person is avoiding this sort of heavy mind expansion other things can be used or salvia can be taken in low doses. Respect the plant and it’s abilities and a person will unlock a new part of their mind.

Reference: http://www.joergo.de/int_siebert_en/

Filed Under: Salvia Divinorum (Ska Pastora) Tagged With: buy salvia, salvia, salvia after effects, salvia divinorum, Salvia Extract

The Outdoor Connect – A Salvia Trip

The Outdoor Connect – A Salvia Trip

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July 4, 2014 By John Reed Leave a Comment

Dose: 2 gram of  Salvia Divinorum extract 20x
Method: Smoked
Body Weight: 170
Gender: Male
Age at time of experience: 30
Experience Year: 2014 

Equipment and Trip Preparation: Just used my glass pipe and a butane torch as equipment. Knew a website I could buy salvia from without fuss so I ordered some up, of the 20x persuasion. Took the day off work, cleaned up the yard and set up my trip area a little, brought out something to play music on. Turned off my alarms and electronics. Put on my light weight waterproof watch and some standard Sunday relaxing t-shirt and shorts combination. I knew what the after-effects would probably feel like so I made some lemonade for later. I brought some pillows outside too in case I didn’t feel like moving for awhile

Mental Status and Environment: Some people like me with low stress life styles (no kids or wife) and easy enough jobs don’t have enough stuff to push them towards a big change. I have used Salvia before to soul search and just for fun, it always takes me deep. I like looking at who I truly am, even if I’m a pretty normal guy I know I have so much potential to unlock beyond my surface.

Tripping inside is very safe in my experience, and that is my go to environment. This time I wanted more, so I went outside. I took my preparation of dry salvia extract , my pipe, my favorite butane torch and sat down in my backyard hammock. It was warm outside but not too uncomfortable for me, I would probably get a little sweaty on the trip anyways.

Dosage: An oversized lump of the 20x salvia extract went into my pipe.

My Salvia Trip:

Salvia Trip - HammockInitial response – I lay back onto my hammock. Totally taken aback by my decision to smoke salvia at all.. I feel like I am transforming in the hammock. I feel like I am becoming electrically connected to it. I’m used to the heavy sinking feelings and I just go deep. There are birds chirping and wildlife springing around me, and I feel them slipping away as I get deeper and deeper into the hammock cocoon. Bright spring light drifts between the branches and leaves shading my hammock. It goes a little dark from there..

Looked at my watch, must have been about 4 minutes had passed. Tried to grab my pipe to smoke more if I had not finished off the bowl. Didn’t know if I wanted to get a more intense trip but I Leaned over and nearly fell out of the hammock. Let out a laugh but my voice was gone. I felt the dirt almost touch my fingers. My backyard was like a warm womb, I just closed my eyes and considered what it might look like in my mind.

I fought the sleepy eyes for awhile, the trip was becoming a nap session in the garden rather than soul searching. I couldn’t look inside when the backyard was so open and the nature was almost consuming. I felt like I was becoming a part of my hammock.patio - Salvia Trip

There was a new connection to my surroundings I had not felt before tripping. This was the feeling I was missing, connection and concern for the nature of reality. Not some room with books and lamps.

Eventually, and I cannot remember why, but I made it out of the hammock and into the grass beneath. I layed in the grass then. I never got the boombox on but I was content enough until the sunset and bugs started biting. With a ton of effort, I remember it was really hard – I got myself inside and enjoyed the lemonade I made earlier that day and went off to sleep.

Experience reports:

  1. Salvia Trip Reports
  2. Salvia 10X Experience: “Recent Salvia Trip of Mine”
  3. Salvia 15X Experience: “The Space Between”
  4. Salvia 20X Experience: “My First Salvia Trip”

Links/Resources:

  1. Salvia Effects
  2. User Guide for Salvia Extract
  3. Salvinorin A experiences (Erowid)

Filed Under: Salvia Trip Reports Tagged With: after effects, buy salvia, salvia, salvia divinorum, Salvia Extract, Salvia trip report

Salvia Art Inspired by Experience

Salvia Art Inspired by Experience

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June 17, 2014 By John Reed Leave a Comment

Salvia Inspired Art Gallery

We picked some very specific Salvia Art that we discovered on the web that remind us of our various Salvia experiences. To us these art piece are reflective of what we have experienced when using Salvia Extract. We hope it will provide you with your own inspiration and encourage you to buy salvia for yourself and participate, grow and learn from Salvia. Enjoy! If you would like to submit other art pieces feel free to e-mail them to us at contact(at)salviaextract.com

Related resources to read up on: What is Salvia divinorum? What are Salvia Effects? How to use Salvia?

Salvia Art
Being put into connection with a divine Salvia Presence
Salvia Art -Aztec Reawakening
Salvia and its deep connection to the Aztec world

 

Salvia Art - Deep inside the Salvia hole
This Salvia art piece is almost a comparison to Alice in WonderWorld I feel its showcasing how you enter different realm with Salvia
Salvia Art - Eternal Awakening
Many Salvia art pieces and experience will speak of a woman. This nicely representative how much of a focal point this women presence takes in a salvia experience

 

Salvia Art - Blinded
Salvia is a much more deeply personally uplifting experience when you keep your eyes closed.
Salvia Art - Bound
I love this Salvia art piece and it reminds me of Salvia because I felt being watched by a good presence but also at the same time secure.

 

Salvia Art - Divine Experiene
This art piece evokes a deeply ancient feel. Salvia has roots going back to Aztec Shamans and was used to connect with the ancient spirit world. With Salvia you feel propelled to a higher level of being and this is a great rep. piece.
Salvia Art - Pulling Forces
Art depicting the competing forces that struggle for control over you. Salvia experiences are also deeply reflected on our day to day feelings

 

Salvia Art
Salvia divinorum a depiction of the potential vision world beyond
Salvia Art - Being Pulled in
Salvia is the most powerful and fastest acting naturally found psychedelic plant. This art shows how fast Salvia acts

 

Useful

Filed Under: Media Tagged With: buy salvia, Diviners Sage, Sage Wisdom, Salvia Art Gallery, salvia divinorum, Salvia Extract, Salvia Inspired Art

How to Make Salvia Extract

How to Make Salvia Extract

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June 3, 2014 By John Reed

How to Make Salvia Extract

Intro on how to make Salvia extract:

This article is meant to instruct a person on how they can easily make Salvia Extract from Salvia Divinorum leaf. You can grow your own Salvia Divinorum at home or buy salvia elsewhere. When making your own salvia extract, be aware that different strains have different strengths. With salvia extraction, you are only amplifying the natural properties of whatever strain you chose to use.

What we know about Salvia Chemistry is that the active ingredient that the plant contains is known as Salvinorin A, this is what you will focus on extracting. This process of extraction yields 10 grams +/- of unstandardized 5x-10x salvia extract, depending on how much you purify it. For 5x strength, complete parts A through D of the instructions. For 10x strength complete all instruction parts.

The instructions and prep list should be followed to the best of your ability. Using any low grade tools could be a danger to your health. If you are clumsy consider buying extras so you wont need to go back out for something. If you are using equipment you already have around the house, clean it up and make it spotless before you get started.

There will be a lot of down time between major parts of the process, be patient and use timers. The whole extraction process should be done in very low light. Exposure to direct sunlight can lower the strength of the extract you are trying to make. Printing out instructions and reading them over several times for clarification can be a big help for first time extractors.

What you need to get started:

  • ½ yard of cheesecloth or a fine metal strainer. No plastic.
  • 1 glass jar, big enough to hold max 1 liter of fluid – about the size of a pickle jar or mason jar. No plastic.
  • 1 glass eyedropper (the kind with a rubber squeeze on the end). No plastic.
  • 1 large Pyrex tray – casserole sized should be fine. No plastic.
  • 1 large aluminum kitchen pan (a sauce pan works too). No plastic.
  • 1 electrical hot plate. The kind you use in a lab or on a camping trip.
  • 1 electric coffee grinder
  • 2 liters of 99% pure pro-panone Acetone. If acetone is not available you can use 99% purity: Isopropanol, Rubbing Alcohol, and Isopropyl Alcohol.
  • 300 milliliters of Naphtha, most commonly found in lighter fluid. You can buy more if you want to purify higher than 10x strength.
  • 100 grams of Salvia Divinorum leaf
  • 1 scale for weighing your leaf, precision up to .01 is best but .1 will work also. Must be able to handle 100g total weight minimum.
  • 1 timer
  • 1 medium sized fan

Extraction Process Instructions:

Part A: Dividing and processing the dried salvia leaf

How to make salvia extract 10 grams of leaves
Weight 10 grams of Salvia Leaves

Use your scale to take 10 grams of leaf out from the 100 grams your are starting with, this is for later use in the process. Keep the 10 grams safe, secure, and somewhere you wont forget. The remaining 90 grams of leaf need to be ground to a fine powder in the coffee grinder. Be nice and gentle with your coffee grinder, do not grind for more than 1 minute at a time. If you grind nonstop the machine may overheat or break. After a few minutes of on and off grinding, you should have the fine green powder. BE CAREFUL when you remove the coffee grinder lid, if you rush it will explode green powder everywhere and this will waste a ton of your leaf.

Salvia Leaves 10 grams Ground down
Grind down 10 grams of Salvia Leaves until finely ground

Part B: Breaking down the ground leaf to extract the Salvinorin A

Salvia with acetone washPlace the 90g of ground leaf in the large saucepan and cover it with the acetone. Stir this mixture for 5 minutes (set your timer so you make sure you do the whole 5 mins). Leave the mixture out of the light in a secure place for 8 hours. This process can be repeated multiple times to extract as much Salvinorin A as
possible – it is dissolving from the ground leaf into the acetone. After your 8 hour wait, pour the liquid through a strainer of your choice (cheesecloth or metal, whatever you bought as long as it isn’t plastic), into the Pyrex container.

 

Strained Acetone from Salvia
Use a cloth to separate the Salvia leaf from the acetone

Part C: Let the acetone liquid settle

The acetone solution you just strained needs to sit for 8 to 16 hours in the Pyrex container, overnight is best to reduce possible exposure to light. Again, keep this solution in a safe and secure location to keep it free from contamination. After this waiting period there will be sediment or a layer of slime looking goo on the bottom of your Pyrex container. The liquid which has separated should be poured off back into the clean saucepan. The goo sediment should stick to the bottom of the container, try not to let any slide into the saucepan with the liquid.

Part D: Evaporate the liquid in a well ventilated area.

You will need to take your saucepan full of the acetone liquid into a well ventilated area. Put the saucepan on your hotplate, with the hotplate set to medium. Aim the fan you have at the saucepan and turn it up to medium-high. Do not use anything which could set off a spark while the fan is expediting the evaporation process. To keep the liquid as stable as possible, avoid direct sunlight and if possible do this evaporation process at night or in a very dark room. The evaporation process can take awhile if you choose to not use a fan. The larger the saucepan the more surface area there is and the faster things will move along.

The current salvia extract you have (once most liquid is gone), is at about 5x strength (aprox). If you are content with the work you’ve put in, you do not need to do any more purification (if you want 10x strength then skip to Part E). If you want your 5x salvia extract, mix in the remaining 10 grams of leaf you set aside to the evaporated, thick and sticky black material you have in your saucepan. Cook this on low hotplate heat with low fan speed. This will eventually become dry salvia extract material and you should let it air dry for another few hours to finish evaporation.

Now you have approximately 10 grams of salvia leaf extract at 5x strength. This is smokeable, however most people choose to continue the purification process to achieve 10x strength or more.

**EXTRA PART FOR BONUS STRENGTH**

Part E: Additional purification for 10x strength extract

Take the cooked down dry salvia extract you have produced from parts A through D and place it in the glass jar – without the 10 grams you set aside. Add 50 ml Naptha to the glass gar with the dry salvia extract. Gently mix the two together, swirl the jar until well mixed. The Naptha will work to break down the dark plant material and separate it from the lighter Salvinorin A. Let this mix sit for 30 minutes. When time is up, use your eyedropper to pull out most of the Naptha from the top of the liquid (carefully discard the naptha), leaving the lighter Salvinorin A material in the jar. Repeat the Naptha mixing and discarding process with the eyedropper until the Salvinorin A material is no longer black. 5 mixes will achieve 10x purity. On your last mix, take out 2/3 of the Naptha and let the rest of the liquid evaporate. The color of your extract should be much lighter than it was at the conclusion of part D.

Once the purified salvia extract you just produced is mostly dry, place it in the clean saucepan you were using before. Add 2 liters of acetone to the saucepan, mix well to be sure the salvia extract is dissolved completely. Add in the remaining 10 grams of dry leaf you set aside (in part A) to your saucepan. Heat this at medium on the hotplate heat with medium-high fan speed. Repeat the evaporation process as you did in part D. This will eventually become dry salvia extract material and you should let it air dry for another few hours to finish evaporation process.

Now you have approximately 10 grams of salvia leaf extract at 10x strength. This is smokeable.

Conclusion

Best results will be achieved by thoroughly following these instructions. For your safety make sure to use only well ventilated spaces. Acetone will dissolve plastic so be careful not to stir any mixtures with it or use any plastic containers. Be careful when discarding all acetone and naptha.

The salvia extract you have produced is appropriate for smoking, it is different than oral consumption liquid like salvia tincture. With the increased strength of any extract it is important to know how to use it, read up on salvia effects before you go in. Finally, be sure to check the legal status of Salvia in your state before attempting to buy any plant material or make any extract.

Filed Under: Salvia Divinorum (Ska Pastora) Tagged With: buy salvia, how to make salvia extract, salvia, salvia divinorum, Salvia Effects, Salvia Extract

Salvia Chemistry

Salvia Chemistry

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May 27, 2014 By John Reed Leave a Comment

Salvia Chemistry

Salvinorin A (chemical formula C23H28O8) is the molecule responsible for the main psychotropic effects of the Salvia divinorum plant. This compound is present in the dried plant at about 0.18%. Active doses start as low as 100-250 micrograms sublingual; 200-500 micrograms vaporized and inhaled. This translates to 10 times the potency of psilocybin from mushrooms used in similar ways by other Mexican Indians, and more than 1000 times the potency of mescaline, from the peyote cactus (Lophophora williamsii) used as a visionary drug by the Huichol, Tarahumara and other native peoples of northern Mexico.

Unique in it’s structure, salvinorin A is considered a diterpenoid and not an alkaloid (opiates fall into this category), due to it’s lack of nitrogen atoms. Morphine, for example, contains carbon, hydrogen, oxygen, and nitrogen. Since salvinorin A only has carbon, hydrogen, and oxygen, it is cannot be broken down into salt as opiates can. It is reported to be the most potent, naturally occurring hallucinogen. Terpenoids, also called isoprenoids, are naturally occurring organic lipids that are found in all living things. Other terpenoids in Salvia divinorum have been isolated and tested, none have yet been linked to the psychoactive aspects of the plant.

There are three main opioid receptor groups called: mu, kappa, and delta. Depending on which ones are activated, different reactions can occur. Research has shown that salvinorin A is a potent κ-opioid (kappa) receptor agonist; meaning that it binds to the receptor and triggers a response by the corresponding cell. Agonists often have the same effect as a naturally occurring substance. The κ-opioid receptor is a protein and one of five receptors that bind opium-like compounds in the brain, controlling the effects of said compounds(including mood, consciousness, motor control, and pain). It also is the main receptor associated with visual hallucinations. Opiates such as morphine also weakly trigger the k-opioid receptor, but also strongly activate the mu-opioid receptor (the receptor which is thought to produce the addictive quality). Salvinorin A triggers only the k-opioid receptor, inducing strong visual hallucinations, without the addictive quality common to other opiates.

Salvinorin A has a high affinity for the receptor, indicated by the low dissociation constant of 1.0 nanomolar (nM), meaning it makes a strong paired bond. It has been reported that the effects of salvinorin A in mice are blocked by κ-opioid receptor antagonists. This makes it unlikely that another mechanism contributes independently to the compound’s observed effects in mice. Salvinorin A has also recently been found to act as a dopamine D2 receptor partial agonist, with an affinity of 5–10 nM, an intrinsic activity of 40–60%, and an EC50 of 50–90 nM, which is several-fold higher than its EC50 of 235 nM for the κ-opioid receptor. The EC50 is a measurement derived from when the concentration of a substance’s response  is halfway between the baseline and maximum after some specified exposure time, i.e. 50% of max response. This suggests that the D2 receptor may also play an important role in its effects.

Molecular structure of salvinorum A

Chemical Makeup of Salvia divinorum

Molecular formula: C23H28O8 
Molecular weight: 432.47 g/mol

Dopamine receptors range from 5 confirmed (D1 to D5) along with a possibility of at least 2 more (D6-D7). They are all ubiquitous throughout the brain, D1-D2 receptors being found in quantities 10-100 times that of D3-D5. Dopamine, being the main neurotransmitter concerning reward pathways in the brain, has long been associated with euphoric effects and drug use.  Many drugs (recreational and prescribed) change the way dopamine is processed, usually limiting the ability of the DAT (dopamine transporter protein) to flush out the dopamine, in turn causing an increase of both dopamine and related signaling (mostly in the D1 and D2 receptors).

There isn’t much data about what dosages cause damage, because even at high doses salvia is non-toxic. Pulse pressure has been reported to elevate slightly (but remained statistically insignificant about 1.5-2 times the control group) and mice chronically given an extremely large dosage did not show signs of organ damage. People who smoked 580 micrograms of the pure drug had urine salvinorin A concentrations of 2.4–10.9 micrograms per liter during the first hour, but the levels fell below the detection limit by 1.5 hours after smoking, indicating that it moves out of the system quickly, or at least at any currently detectable levels.

Filed Under: Salvia Divinorum (Ska Pastora) Tagged With: buy salvia, chemistry of salvia, salvia, salvia divinorum

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